Treating critically ill patients with intravenous ibuprofen

摘要

Methods of treating at least one condition chosen from pain, inflammation, and fever in a critically ill patient in need thereof, comprising administering to the critically ill patient an intravenous pharmaceutical composition comprising ibuprofen using a first dosage regimen, wherein the first dosage regimen produces a first pharmacokinetic profile in critically ill patients that is about equivalent to a second pharmacokinetic profile produced by administration of the intravenous pharmaceutical composition using a second dosage regimen of ibuprofen to non-critically ill patients, wherein the at least one condition of the critically ill patient is thereby treated.

主权项

1. A method of treating pain in critically ill patients in need thereof, comprising intravenously administering to a critically ill patient an ibuprofen pharmaceutical composition in a dose of about 400 mg, to attain a mean Cmax within about 80% to about 125% of 25.7 μg/ml and a mean (AUC)0-4 within about 80% to about 125% of 45.9 μg·h/ml, the critically ill patient receiving at least one treatment selected from vasopressor support and mechanical ventilation, wherein the patients are not being treated for inflammation and the dose of ibuprofen administered intravenously to the critically ill patient provides a Cmax and AUC which is about one-half of the Cmax and AUC obtained when the same dose is intravenously administered to a non-critically ill patient.