发明名称 |
TUMOR-SELECTIVE ADENOVIRUS E1A AND E1B MUTANTS |
摘要 |
Modified Ela regulatory sequences are provided, wherein at least one Pea3 binding site, or a functional portion thereof, is deleted. Also provided are modified E1a sequences that selectively express particular isoforms. Also provided is an E1b-19K clone insertion site. These modified sequences can be used individually, or in combination with one another, to provide tumor-selective expression of proteins. |
申请公布号 |
HRP20151396(T1) |
申请公布日期 |
2016.03.25 |
申请号 |
HR2015P001396T |
申请日期 |
2015.12.21 |
申请人 |
The Regents of the University of California |
发明人 |
Reid, Tony;Hedjran, Farah;Kumar, Shantanu |
分类号 |
C12N15/861;C12N5/10;C12N15/12 |
主分类号 |
C12N15/861 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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