EXCIPIENTS FOR USE IN ADENO-ASSOCIATED VIRUS PHARMACEUTICAL FORMULATIONS, AND PHARMACEUTICAL FORMULATIONS MADE THEREWITH

摘要

PROBLEM TO BE SOLVED: To provide formulations for storing rAAV virions.SOLUTION: Stable pharmaceutical compositions comprising recombinant adeno-associated virus (AAV) virions are described. The compositions provide protection against loss of recombinant AAV vector genomes and transduceability under conditions such as exposure to cycles of freezing and thawing and storage in glass or polypropylene vials. The compositions comprise AAV viruses in combination with one or more dihydric or polyhydric alcohols, and, optionally, a surfactant, such as a sorbitan ester. Also described are methods of using the compositions.SELECTED DRAWING: None