Compositions of Glycopyrronium Salt for Inhalation

摘要

A process for preparing dry powder formulations of a glycopyrronium salt for inhalation that have good stability. The process involves (a) micronising a glycopyrronium salt together with an anti-adherent agent, and (b) admixing carrier particles to form the dry powder formulation.

主权项

1. A process for preparing a dry powder formulation of a glycopyrronium salt for inhalation that comprises the steps of (a) mixing a glycopyrronium salt and to 5% by mass of magnesium stearate, based on the total amount of glycopyrronium salt and magnesium stearate, to give a homogeneous blend; (b) micronising the blend; and (c) admixing carrier particles to the micronized blend to form a dry powder formulation, wherein the carrier particles are mixed with the blend of micronized glycopyrronium salt and magnesium stearate in a ratio of 200:1 to 20:1 by mass.