发明名称 |
COMPOUNDS AND METHODS FOR ENHANCING VIRAL GENE TRANSFER TO HUMAN HEMATOPOIETIC CELLS |
摘要 |
Methods and compositions for enhancing viral gene transfer, such as lentiviral gene transfer, and improving the efficacy of gene delivery to cells such as primitive hematopoietic cells, are described. These methods and compositions are based on the use of pyrimido[4,5- b]indole derivatives. Cell-based compositions and methods useful for therapeutic indications amenable to treatment with gene therapies, including hematopoietic stem cell therapies, are also described. |
申请公布号 |
WO2016041080(A1) |
申请公布日期 |
2016.03.24 |
申请号 |
WO2015CA50907 |
申请日期 |
2015.09.17 |
申请人 |
UNIVERSITÉ DE MONTRÉAL;BC CANCER AGENCY;FRED HUTCHINSON CANCER RESEARCH CENTER |
发明人 |
SAUVAGEAU, GUY;HUMPHRIES, KEITH RICHARD;KIEM, HANS-PETER;FARES, IMAN;CHAGRAOUI, JALILA |
分类号 |
C12N15/87;A61K35/12;A61K35/28;A61K48/00;C07D487/04;C07K5/083;C07K5/10;C12N5/0789;C12N15/86;C12N15/867 |
主分类号 |
C12N15/87 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|