发明名称 |
SPRAY-FREEZE DRYING OF POLYELECTROLYTE NANOPARTICLES CONTAINING THE PROTEIN DRUG |
摘要 |
The present invention relates to a process for spray-freeze-drying (SFD) a dispersion of polyelectrolyte complex (PEC) nanoparticles loaded with a protein drug, which yields a powdered product with adequate flowability properties that may readily be processed further into solid dosage forms such as tablets or capsules. The mean particle size of PEC nanoparticles obtained after redispersion of SFD powder or pharmaceutical compositions made from said powder in water is preserved in the nanometer range (< 1000 nm), and so is the protein biological activity. |
申请公布号 |
WO2016042121(A1) |
申请公布日期 |
2016.03.24 |
申请号 |
WO2015EP71410 |
申请日期 |
2015.09.18 |
申请人 |
LEK PHARMACEUTICALS D.D. |
发明人 |
CEGNAR, MATEJA;AVANZO, MATEJ;KERC, JANEZ;MIKLAVZIN, ANA |
分类号 |
A61K9/16;A61K9/20;A61K9/51;A61K38/18;A61K38/19 |
主分类号 |
A61K9/16 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|