TRANSDERMAL FORMULATIONS OF FLUTICASONE

摘要

The present invention generally relates to the transdermal delivery of fluticasone and other glucocorticoids. In some aspects, transdermal delivery may be facilitated by the use of a hostile biophysical environment, for example, a high ionic strength environment. One set of embodiments provides a composition for transdermal delivery comprising fluticasone and/or a salt thereof, and optionally, a nitric oxide donor. Other glucocorticoids can also be used in some cases. Such compositions may be used to facilitate the delivery of effective amounts of fluticasone or other glucocorticoids systemically or to deeper tissues, rather than only locally or superficially, and in some cases, the effects of fluticasone or other glucocorticoids may be prolonged for unexpectedly long periods of time, e.g., days or weeks.

主权项

1. A composition for transdermal delivery, the composition comprising:
an ionic salt at a concentration of at least about 5 wt %; and fluticasone and/or a salt thereof.