发明名称 PARTHENOLIDE DERIVATIVES AND THEIR MODULATION OF PROCESSES CONTROLLED BY REGULATED TRANSLATION
摘要 The present invention provides parthenolide derivatives. In particular, the present invention provides parthenolide derivatives that modulate processes controlled by regulated mRNA translation and have anticancer activity.
申请公布号 US2016083397(A1) 申请公布日期 2016.03.24
申请号 US201414785183 申请日期 2014.04.18
申请人 PENTHALA Narsimha Reddy;CROOKS Peter;JANGANATI Venumadhav;THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ARKANSAS 发明人 Penthala Narsimha Reddy;Crooks Peter;Janganati Venumadhav
分类号 C07D493/08 主分类号 C07D493/08
代理机构 代理人
主权项 1. A method for modulating a process controlled by regulated mRNA translation, the method comprising contacting a cell with an effective amount of a compound comprising Formula (I) or a pharmaceutically acceptable salt thereof, whereby the process controlled by regulated mRNA translation is attenuated or activated, the compound comprising Formula (I): wherein: R1 is hydrogen, hydrocarbyl, or substituted hydrocarbyl;R2, R3, R6, and R7 are independently hydrogen, hydroxyl, keto, halo, amine, amide, nitro, phospho, cyano, thiol, hydrocarbyl, or substituted hydrocarbyl;R4, R5, and R8 are independently hydrogen, hydroxyl, halo, amine, amide, nitro, phospho, thiol, hydrocarbyl, or substituted hydrocarbyl; and----- is a double or single bond.
地址 Little Rock AR US