Progenitor endothelial cell capturing with a drug eluting implantable medical device

摘要

A medical device for implantation into vessels or luminal structures within the body is provided. The medical device, such as a stent and a synthetic graft, is coated with a pharmaceutical composition consisting of a controlled-release matrix and one or more pharmaceutical substances for direct delivery of drugs to surrounding tissues. The coating on the medical device further comprises a ligand such as an antibody or a small molecule for capturing progenitor endothelial cells in the blood contacting surface of the device for restoring an endothelium at the site of injury. In particular, the drug-coated stents are for use, for example, in balloon angioplasty procedures for preventing or inhibiting restenosis.

主权项

1. An artificial heart valve, having a coating, wherein the coating comprises a plurality of antibodies, antibody fragments or combinations thereof, wherein the coating further comprises a pharmaceutical substance that inhibits smooth muscle cell migration and/or proliferation, wherein the plurality of antibodies, antibody fragments or combinations thereof specifically bind to a cell surface antigen of endothelial progenitor cells or endothelial cells.