COMPLEXES OF CANAGLIFLOZIN AND CYCLODEXTRINS

摘要

The present invention relates to complexes of canagliflozin of formula I, (lS)-1,5-anhydro-1- (3-((5-(4-fluorophenyl)-2-thienyl)methyl)-4-methylphenyl)-D-glucitol; with cyclodextrins and a method of their preparation. These complexes can be advantageously used for stabilization of amorphous canagliflozin in terms of the chemical and polymorphic stability, β- Cyclodextrin, modified β-cyclodextrins and γ-cyclodextrin can be particularly used for the complexation of canagliflozin.