PROTEIN DISULFIDE ISOMERASE ASSAY METHODS FOR IN VITRO DIAGNOSIS OF COLORECTAL CANCER

摘要

PROBLEM TO BE SOLVED: To provide monoclonal anti-protein disulfide isomerase (PDI) monoclonal antibodies for use in diagnosis of colorectal cancer by determining the presence of PDI being a cellular thyroid hormone binding protein.SOLUTION: Described herein: PDI epitopes being three peptides of specified amino acid sequences; anti-PDIA1 monoclonal antibodies that bind to the PDI epitopes (PDIA1); and methods for using the anti-PDIA1 monoclonal antibodies for early diagnosis, screening, therapeutic follow-up, prognosis and relapse diagnosis in relation to colorectal cancer.SELECTED DRAWING: None