| 摘要 |
PROBLEM TO BE SOLVED: To provide methods for treating a subject who has or is at risk of developing hearing loss or vestibular dysfunction.SOLUTION: The invention relates to methods for administering &bgr;-catenin polypeptide, secreted cysteine-rich glycoprotein/&bgr;-catenin pathway agonist, glycogen synthase kinase 3&bgr; inhibitor, casein kinase 1 inhibitor, and γ secretase inhibitor to an inner ear systemically or topically; or for administering a population of cells capable of differentiating into hair cells in which &bgr;-catenin expression or activity is increased to an ear.SELECTED DRAWING: None |
