发明名称 2'-CHLORO NUCLEOSIDE ANALOGS FOR HCV INFECTION
摘要 Provided herein are compounds, compositions and methods for the treatment of Flaviviridae infections, including HCV infections. In certain embodiments, compounds and compositions of nucleoside derivatives are disclosed, which can be administered either alone or in combination with other anti-viral agents. In certain embodiments, the compounds are 2′-chloro nucleosides according to Formula 2001:;;or a pharmaceutically acceptable salt, solvate, stereoisomeric form, tautomeric form or polymorphic form thereof, wherein B, Z and PD are as described herein.
申请公布号 US2016083413(A1) 申请公布日期 2016.03.24
申请号 US201514920830 申请日期 2015.10.22
申请人 Idenix Pharmaceuticals, Inc. ;Centre National De La Recherche Scientifique ;Universite Montpellier 2 Sciences Et Techniques 发明人 Gosselin Gilles;Parsy Christophe Claude;Alexandre François-René;Rahali Houcine;Griffon Jean-François;Surleraux Dominique;Dousson Cyril B.;Pierra Claire;Moussa Adel M.;Mayes Benjamin Alexander;Stewart Alistair James;Dukhan David
分类号 C07H19/10;A61K45/06;A61K31/7072 主分类号 C07H19/10
代理机构 代理人
主权项
地址 Cambridge MA US