摘要 |
Provided herein are multicyclic compounds, methods of their synthesis, pharmaceutical compositions comprising the compounds, and methods of their use. The compounds provided herein are useful for the treatment, prevention, and/or management of various neurological disorders, including but not limited to, psychosis and schizophrenia. |
主权项 |
1. A compound of formula (IVa):or a pharmaceutically acceptable salt or stereoisomer thereof, wherein
(i) R1 and R3 together with the atoms to which they are attached form an optionally substituted heterocyclyl, and R4 is hydrogen or alkyl; or (ii) R3 and R4 together form a double bond and together with R1 and the atoms to which they are attached form an optionally substituted heteroaryl; R2 is hydrogen, alkyl, or absent; R5 is hydrogen or alkyl; R6 and R7 are each independently (i) hydrogen, halo, alkyl, alkoxyl, aminoalkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, or aralkyl, each of which is optionally substituted; or (ii) —(CH2)p—R11, wherein R11 is CF3, CN, nitro, amino, hydroxyl, cycloalkoxyl, heteroaryl, or heterocyclyl, each of which is optionally substituted; m is 0, 1, or 2; n is 0, 1, or 2; and each occurrence of p is independently 0, 1, or 2. |