| 主权项 |
1. A compound of formula (I): and/or a pharmaceutically acceptable salt thereof, wherein:
Z1 and Z2 are independently selected from C and N;a moiety is R1, R2, and R5 are independently selected from:hydrogen,halogen,CN,nitro,NH2,(CH2)m-Q,C1-6 alkyl,C2-6 alkenyl,C2-6 alkynyl,C3-10 cycloalkyl, andwherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl and C3-10 cycloalkyl are each unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from R7;Q is selected fromaryl,heteroaryl,C3-10 cycloalkyl, andheterocyclyl,wherein aryl, heteroaryl, C3-10 cycloalkyl, and heterocyclyl are each unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from R8;R3, R4, and R6 are independently selected from:hydrogen,halogen,CN,nitro,C1-6 alkyl,C2-6 alkenyl, andC2-6 alkynyl,wherein C1-6 alkyl, C2-6 alkenyl and C2-6 alkynyl are each unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from R7;each R7 is independently selected from:halogen,CN,nitro,C(═O)Rb,C(═O)ORb,C(═O)NRaRa,C(═NRa)NRaRa,ORa,OC(═O)Rb,OC(═O)NRaRa,OC1-6 alkylN(Ra)C(═O)ORb,OC(═O)N(Ra)S(═O)2Rb,OC2-6 alkylNRaRa,OC2-6 alkylORa,SRa,S(═O)Rb,S(═O)2Rb,S(═O)2NRaRa,S(═O)2N(Ra)C(═O)Rb,S(═O)2N(Ra)C(═O)ORb,S(═O)2N(Ra)C(═O)NRaRa,(CRcRc)nNRaRa,N(Ra)C(═O)Rb,N(Ra)C(═O)ORb,N(Ra)C(═O)NRaRa,N(Ra)C(NRa)NRaRa,N(Ra)S(═O)2Rb,N(Ra)S(═O)2NRaRa,NRaC2-6 alkylNRaRa,NRaC2-6alkylORa,(CRcRc)nC4-8 heterocycloalkyl,(CRcRc)n aryl,(CRcRc)n heteroaryl,(CRcRc)nO(CRcRc)n aryl,(CRcRc)nC3-8cycloalkyl,(CRcRc)nC4-8 heterocycloalkyl,(CRcRc)nO(CRcRc)nCF3,(CRcRc)n N(CRcRc)nORa,(CRcRc)nN(Ra)(CRcRc)n aryl,(CRcRc)nN(Ra)(CRcRc)n heteroaryl,(CRcRc)nO(CRcRc)n heteroaryl,C1-6 alkyl,C2-6 alkenyl, andC2-6 alkynyl,wherein C1-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, C3-8 cycloalkyland C4-8 heterocycloalkyl are each unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from:halogen,oxo,CI-6 alkyl,CN,nitro,C(═O)Rb,C(═O)ORb,C(═O)NRaRa,C(NRa)NRaRa,ORa,OC(═O)Rb,OC(═O)NRaRa,OC(═O)N(Ra)S(═O)2Rb,OC2-6 alkylNRaRa,OC2-6 alkylORa,SRa,S(═O)Rb,S(═O)2Rb,S(═O)2NRaRa,S(═O)2N(Ra)C(═O)Rb,S(═O)2N(Ra)C(═O)ORb,S(═O)2N(Ra)C(═O)NRaRa,NRaRa,N(Ra)C(═O)Rb,N(Ra)C(═O)ORb,N(Ra)C(═O)NRaRa,N(Ra)C(═NRa)NRaRa,N(Ra)S(═O)2Rb,N(Ra)S(═O)2NRaRa,NRaC2-6alkylNRaRa,NRaC2-6alkylORa,N(Ra)(CRaRa)n—Y,(CRaRa)n—Y,(CRaRa)nC3-8 cycloalkyl, and(CRaRa)nORa;each R8 is independently selected from:halogen,oxo,OCHF2,OCF3,CN,nitro,C(═O)Rb,C(═O)ORb,C(═O)NRaRa,C(═NRa)NRaRa,ORa,OC(═O)Rb,OC(═O)NRaRa,OC1-6 alkylN(Ra)C(═O)ORb,OC(═O)N(Ra)S(═O)2Rb,OC2-6 alkylNRaRa,OC2-6 alkylORa,SRa,S(═O)Rb,S(═O)2Rb,S(═O)2NRaRa,S(═O)2N(Ra)C(═O)Rb,S(═O)2N(Ra)C(═O)ORb,S(═O)2N(Ra)C(═O)NRaRa,NRaRa,N(Ra)C(═O)Rb,N(Ra)C(═O)ORb,N(Ra)C(═O)NRaRa,N(Ra)C(═NRa)NRaRa,N(Ra)S(═O)2Rb,N(Ra)S(═O)2NRaRa,NRaC2-6alkylNRaRa,NRaC2-6 alkylORa,C1-6 alkyl,C2-6 alkenyl, andC2-6 alkynyl,wherein C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl are each unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from:halogen,CN,nitro,C(═O)Rb,C(═O)ORb,C(═O)NRaRa,C(═NRa)NRaRa,ORa,OC(═O)Rb,OC(═O)NRaRa,OC(═O)N(Ra)S(═O)2Rb,OC2-6 alkylNRaRa,OC2-6 alkylORa,SRa,S(═O)Rb,S(═O)2Rb,S(═O)2NRaRa,S(═O)2N(Ra)C(═O)Rb,S(═O)2N(Ra)C(═O)ORb,S(═O)2N(Ra)C(═O)NRaRa,NRaRa,N(Ra)C(═O)Rb,N(Ra)C(═O)ORb,N(Ra)C(═O)NRaRa,N(Ra)C(═NRa)NRaRa,N(Ra)S(═O)2Rb,N(Ra)S(═O)2NRaRa,NRaC2-6 alkylNRaRa,NRaC2-6 alkylORa,N(Ra)(CRaRa)n—Y,(CRaRa)n—Y, and(CRaRa)nORa;each Ra is independently selected from hydrogen and Rb;each Rb is independently selected from:C1-6 alkyl,C2-6 alkenyl,C2-6 alkynyl,aryl,heteroaryl,C3-8 cycloalkyl, andC4-8 heterocycloalkyl,wherein the CI-6 alkyl, C2-6 alkenyl, C2-6 alkynyl, aryl, heteroaryl, C3-8 cycloalkyl and C4-8 heterocycloalkyl are each unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from:halogen,CN,OH,S(═O)2Rb,OC2-6 alkylORa,CI-4 alkyl,CI-3 haloalkyl,OCI-4 alkyl,NH2, andNRaRa;or Ra and Rb together with the carbon atoms and/or heteroatoms to which they are attached can form a 4-10 membered ring containing 0, 1, 2 or 3 heteroatoms independently selected from sulfur and nitrogen;each Rc is independently selected from:hydrogen,ORa,NRaRa,CI-6 alkyl, andCRcRc can form a C3-8 cycloalkyl ring;Y is selected from:aryl,heteroaryl,C3-10 cycloalkyl, andheterocyclyl,wherein aryl, heteroaryl, C3-10 cycloalkyl, and heterocyclyl are each unsubstituted or substituted with at least one substituent, such as one, two, three, or four substituents, independently selected from:C1-8 alkyl,C2-6 alkenyl,C2-6 alkynyl,CI-4 haloalkyl,halogen,CN,nitro,C(═O)Rb,C(═O)ORb,C(═O)NRaRa,C(NRa)NRaRa,ORa,OC(═O)Rb,OC(═O)NRaRa,OC(═O)N(Ra)S(═O)2Rb,OC2-6 alkylNRaRa,OC2-6 alkylORa,SRa,S(═O)Rb,S(═O)2Rb,S(═O)2NRaRa,S(═O)2N(Ra)C(═O)Rb,S(═O)2N(Ra)C(═O)ORb,S(═O)2N(Ra)C(═O)NRaRa,NRaRa,N(Ra)C(═O)Rb,N(Ra)C(═O)ORb,N(Ra)C(═O)NRaRa,N(Ra)C(═NRa)NRaRa,N(Ra)S(═O)2Rb,N(Ra)S(═O)2NRaRa,NRaC2-6alkylNRaRa, andNRaC2-6 alkylORa;each m is selected from 0, 1, 2, 3, and 4,each n is independently selected from 0, 1, 2, and 3. |
