| 主权项 |
1. A composition, in the form of an aqueous solution, comprising insulin in hexameric form, at least one substituted anionic compound of non-saccharide structure and at least one polyanionic compound other than said substituted anionic compound, wherein the substituted anionic compound corresponds to formula I below:wherein
R represents a saturated or unsaturated, linear, branched or cyclic hydrocarbon-based radical comprising from 1 to 12 carbon atoms, optionally comprising at least one function chosen from ether, alcohol and carboxylic acid functions. AA is a radical resulting from an aromatic amino acid comprising a phenyl group or an indole group, which is substituted or not substituted, or an aromatic amino acid derivative comprising a phenyl group or an indole group, which is substituted or not substituted, said radical AA bearing at least one free acid function, E represents an at least divalent radical, comprising from 2 to 6 carbon atoms, F, F′ and F″ represent, independently of each other, a function chosen from amide, carbamate and urea functions, F and F″ being functions resulting from a reaction involving the amine of the aromatic amino acid, the precursor of the radical AA, F′ being a function involving a reactive function of the precursor of R and a reactive function of the precursor of E, p being an integer between 1 and 3, m is an integer between 0 and 6; n is an integer between 0 and 6; m+n is an integer between 1 and 6;said compound comprising at least two carboxylic acid functions in the form of a salt of an alkali metal chosen from Na+ and K+. |
