INHIBITORS OF METALLO-ß-LACTAMASE-ENZYMES

摘要

The present application relates to combination treatments for bacterial infections. For example, the application relates to the use of one or more β-lactam antibiotics and one or more compounds of Formula I: (I) for treatment of a metallo-B-lactamase-expressing bacterial infection or a disease, disorder or condition arising from a metallo-B-lactamase-expressing bacterial infection.

主权项

1. A pharmaceutical composition comprising:
one or more β-lactam antibiotics; and one or more compounds of Formula I:whereinR1 is selected from C(O)OR5, C(O)NHR5 and CH(NH2)C(O)OR5;R2, R3, R4 and R5 are independently selected from H, C1-24alkyl, C1-6alkyleneC6-10aryl, C1-6alkyleneC3-10cycloalkyl, C1-6alkyleneC3-10heterocycloalkyl and C1-6alkylene-OC(O)C1-6alkyl; andn, m and p are independently selected from 1 and 2;or a pharmaceutically acceptable salt and/or solvate thereof, andthe one or more β-lactam antibiotics and one or more compounds of Formula I are present in amounts that are effective to treat a bacterial infection, or a disease, disorder or condition arising from a bacterial infection.