Integrated Sequencing Apparatuses And Methods Of Use

摘要

Provided are methods and apparatuses for performing sequencing using electrowetting-based techniques. Also provided are integrated methods and apparatuses for performing sample preparation and sequencing on the same 5 apparatus. In addition, provided are methods of reducing reagent waste and preloaded consumable cartridges comprising reagents for sample preparation and/or sequencing. WO 2013/070627 PCT/US20 12/063741 Electrodes Liquid flow -l D Substrate mole -~A -------- detection pixels Fig. 1 Electrodes Top of flowcell Flowcell Liquid fDNA Substrate molecules ------ CMOS chip ----------. ./... ---- detection pixeVs Fig. 2 Fig. 3