WOVEN HYDROGEL BASED BIOSENSOR

摘要

A porous hydrogel sensor that is responsive to the presence of one or more target compounds in solution is synthesized based on demixing of certain molecules in the presence of a target compound. The porous hydrogel sensor may include fluorescently tagged antibodies that are noncovalently bound to the gel and then released in the presence of the target antigen. The porous hydrogel sensor may alternatively include dissolvable cross-links using polymerized antibody and antigen complexes so that, in the presence of the target antigen, the cross-links will be displaced and the hydrogel will dissolve.

主权项

1. A sensor for detecting a target compound, comprising:
a porous hydrogel having a first water-soluble monomer copolymerized with a second water-soluble polymer, wherein some of said second polymer is covalently bound to an antigen indicative of said target compound and some of said second monomer is covalently bound to an antibody to said antigen, and wherein said hydrogel is non-covalently cross-linked by said antigen and said antibody.