DETECTING COMPLEMENT ACTIVATION

摘要

Methods of detecting complement activation including steps of detecting in a sample from a subject a level of iC3b wherein the detecting involves specific interaction between the iC3b and a non-cross-reactive antibody thereto, comparing the detected level with a reference level, which reference level is within a range of about 10 ng/ml to about 5,000 ng/ml, wherein determination that the detected level is above the reference level indicates that the subject is suffering from or susceptible to undesirable and/or pathologic complement activation, and administering treatment to treat undesired complement activation if the detected level is above the reference level. Other methods of detecting complement activation with or without measuring iC3b are also provided.

主权项

1. A method comprising steps of
detecting in a sample from a subject a level of intact C3, wherein the detecting involves specific interaction between the intact C3 and a non-cross-reactive antibody thereto; comparing the detected level with a reference level, which reference level is within a range of about 350 ug/ml to about 1,700 ug/ml; wherein determination that the detected level is below the reference level indicates that the subject is suffering from or susceptible to undesirable and or/pathologic complement activation; and administering treatment to treat undesired complement activation if the detected level is below the reference level.