| 发明名称 |
CHEMICAL EXCHANGE SATURATION TRANSFER (CEST) BASED MRI USING REPORTER GENES AND SUBSTRATES AND METHODS THEREOF |
| 摘要 |
The present invention features polypeptide or protein based reporters, wherein the MRI contrast is generated by the protein itself, and methods, MRI systems and MRI imaging kits related thereto. The present invention also features enzyme based reporters, wherein the contrast is generated by the substrate/product of an enzyme, and methods, MRI systems and MRI imaging kits related thereto. |
| 申请公布号 |
US2016082133(A1) |
申请公布日期 |
2016.03.24 |
| 申请号 |
US201414785495 |
申请日期 |
2014.04.15 |
| 申请人 |
The Johns Hopkins University |
发明人 |
Gilad Assaf A.;Bar-Shir Amnon;Bulte Jeff W.M.;Liu Guanshu;Airan Raag D.;McMahon Michael T.;van Zijl Peter C. M. |
| 分类号 |
A61K49/12;A61B5/055 |
主分类号 |
A61K49/12 |
| 代理机构 |
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代理人 |
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| 主权项 |
1. A method for obtaining an image by MRI, comprising:
introducing one or more genes into cells to be imaged, wherein the one or more genes are reporter genes or reporter substrate genes; and imaging the cells using a Chemical Exchange Saturation Transfer (CEST) based MRI technique. |
| 地址 |
Baltimore MD US |
