发明名称 |
BISPECIFIC INTRACELLULAR DELIVERY VEHICLES |
摘要 |
A composition for delivering an agent to a cell, comprising a bispecific affinity reagent and a pH-responsive, membrane destabilizing polymer. The bispecific affinity reagent may include a first affinity reagent covalently linked to a second affinity reagent, wherein the first affinity reagent binds to a molecule on the surface of a cell, and the second affinity reagent binds to an intracellular target. |
申请公布号 |
US2016082121(A1) |
申请公布日期 |
2016.03.24 |
申请号 |
US201514957429 |
申请日期 |
2015.12.02 |
申请人 |
PhaseRx, Inc. ;University of Washington |
发明人 |
Stayton Patrick S.;Hoffman Allan S.;Convertine Anthony;Duvall Craig L.;Overell Robert;Johnson Paul |
分类号 |
A61K47/48;C07K16/40;C07K16/18;C07K16/28 |
主分类号 |
A61K47/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Seattle WA US |