INHIBITORS OF THE Eph-A RECEPTOR AND USES THEREOF

摘要

Eph A receptor inhibitor peptides, and particularly Eph A4 receptor inhibitor peptides, are provided. The peptides comprise a sequence derived from the G-H loop of ephrin A4. Further, pharmaceutical compositions comprising said peptides and use thereof in treating, ameliorating or preventing diseases associated with memory formation are provided.

主权项

1. An isolated peptide, comprising an amino acid sequence as set forth in SEQ ID NO: 1 (QRX1TPFX2LGFE), wherein X1 is Tyr (Y) or Phe (F) and X2 is Pro (P) or Ser (S), or a sequence having a conservative substitution relative to SEQ ID NO: 1.