| 发明名称 |
Immunoconjugates with an Intracellularly-Cleavable Linkage |
| 摘要 |
The present invention relates to therapeutic conjugates with improved ability to target various diseased cells containing a targeting moiety (such as an antibody or antibody fragment), a linker and a therapeutic moiety, and further relates to processes for making and using the conjugates. |
| 申请公布号 |
US2016082003(A1) |
申请公布日期 |
2016.03.24 |
| 申请号 |
US201514956769 |
申请日期 |
2015.12.02 |
| 申请人 |
Immunomedics, Inc. |
发明人 |
Govindan Serengulam V.;Moon Sung-Ju;Goldenberg David M. |
| 分类号 |
A61K31/4745;A61K47/48;A61N5/10;C07K16/30;A61K45/06;C07K16/28;C07K16/18 |
主分类号 |
A61K31/4745 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method for treating autoimmune disease, comprising administering to a subject with an autoimmune disease a conjugate having a structural formula MAb-CL2A-SN-38, with a structure represented by: wherein said MAb binds to HLA-DR antigen. |
| 地址 |
Morris Plains NJ US |
