发明名称 |
ORALLY ADMINISTRABLE COMPOSITIONS AND METHODS OF DETERRING ABUSE BY INTRANASAL ADMINISTRATION |
摘要 |
The present invention provides an orally administrable pharmaceutical composition comprising a drug and one or more pharmaceutically acceptable excipients in an amount sufficient to deter abuse by nasal insufflation, wherein the pharmaceutical composition is configured such that when the pharmaceutical composition is intranasally administered in physically compromised form to a subject, the Cmax and/or AUG of the drug achieved after a time period is lower than the Cmax and/or AUG of the drug achieved after intranasal administration of a physically compromised form of an orally bioequivalent composition not containing one or more pharmaceutically acceptable excipients in an amount sufficient to deter abuse by nasal insufflation. |
申请公布号 |
WO2016043698(A1) |
申请公布日期 |
2016.03.24 |
申请号 |
WO2014US55616 |
申请日期 |
2014.09.15 |
申请人 |
INSPIRION DELIVERY TECHNOLOGIES, LLC |
发明人 |
SHAH, MANISH S.;DIFALCO, RAY J.;AIGNER, STEFAN |
分类号 |
A61K31/485 |
主分类号 |
A61K31/485 |
代理机构 |
|
代理人 |
|
主权项 |
|
地址 |
|