发明名称 |
NANOPARTICLE-BASED COMBINATORIAL THERAPY |
摘要 |
The present invention provides a nano-particle based structure or composition for a combinational cancer therapy. The structure has a doxorubicin (DOX) physically loaded on core-shell silver polymeric nanoparticles (AgNPs) with a ratio of 3.3-5.5% doxorubicin to 1% silver to 2-10% polymer. This structure enhances the cellular uptake of DOX in comparison to the current conventional combination therapy. The DOX-loaded nano-particles result in an improved the therapeutic efficiency of DOX, and reduced its toxicity, which cannot occur in case of adding DOX and AgNPs. |
申请公布号 |
WO2016044716(A1) |
申请公布日期 |
2016.03.24 |
申请号 |
WO2015US50926 |
申请日期 |
2015.09.18 |
申请人 |
THE AMERICAN UNIVERSITY IN CAIRO |
发明人 |
ELBAZ, NANCY MOHAMED;AHMED, WAEL MAMDOUH SAYED SAYED;ZIKO, LAILA;SIAM, RANIA |
分类号 |
A61K9/58;A61K31/135;A61K33/38 |
主分类号 |
A61K9/58 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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