| 摘要 |
PROBLEM TO BE SOLVED: To provide improved parvovirus for therapeutic uses.SOLUTION: Compared with wild type parvovirus, parvovirus variants exhibit high anti-tumor ability, which variants are characterized by: (a) amino acid substitution, alteration or addition, preferably substitution at position Lys96 of NS-2 and/or position Leu103 of NS-2, (the latter case also involves amino acid substitution at position Tyr595 of NS-1); or (b) in-frame deletion, preferably deletion resulting in a large amino acid deletions in both the central portion (amino acids 96-133) of NS-2 and C terminal portion (amino acids 587-624) of NS-1. A method for using the parvovirus variants for cancer therapy.SELECTED DRAWING: None |
