| 摘要 |
PROBLEM TO BE SOLVED: To provide genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein, genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein that have been engrafted with human cells such as human hematopoietic cells, and methods for making such engrafted mice.SOLUTION: The genetically modified mice comprising a nucleic acid sequence encoding a human M-CSF protein find use in a number of applications, such as in modeling human immune disease and pathogen infection; in in vivo screens for agents that modulate hematopoietic cell development and/or activity, e.g. in a healthy or a diseased state; in in vivo screens for agents that are toxic to hematopoietic cells; in in vivo screens for agents that prevent against, mitigate, or reverse the toxic effects of toxic agents on hematopoietic cells; in in vivo screens of human hematopoietic cells from an individual to predict the responsiveness of an individual to a disease therapy, etc.SELECTED DRAWING: Figure 2A |
