CHIMERIC FACTOR H BINDING PROTEINS (FHBP) AND METHODS OF USE THEREOF

摘要

PROBLEM TO BE SOLVED: To provide unique factor H binding protein (fHbp) polypeptide that can elicit bactericidal antibody response against strains of wide range expressing different variants of fHbp.SOLUTION: A first analysis of 69 unique fHbp sequences and a second analysis of all 275 peptide IDs revealed that several different stretches of amino acid sequences within the fHbp are conserved among all the fHbps analyzed, based on which, chimeric fHbps that can elicit antibodies that are bactericidal for different fHbp variant strains of N. meningitidis are provided.SELECTED DRAWING: Figure 13