SYNTHESIS OF ISOHEXIDE DICARBAMATES AND DERIVATIVES THEREOF

摘要

Isohexide dicarbamates and a method of preparing the same are described. The method involves reacting a mixture of an isohexide and a cynate salt in a non-aqueous solvent, with a miscible acid having a pKa of about 3.7 or less. The isohexide dicarbamates can serve as precursor materials from which various derivative compounds can be synthesized.

主权项

1. A process for preparing dicarbamates of 1,4:3,6-dianhydrohexitols, the process comprising: providing a mixture of an isohexide with a cyanate salt in an inert organic solvent, reacting said mixture with an acid having a pKa≦3.7.