发明名称 |
PYRAZINOISOQUINOLINE COMPOUNDS |
摘要 |
This invention in one embodiment is directed to a compound of Formula Ia;;;where the designation (R) indicates that the designated carbon has the (R) stereochemistry; and wherein Z1 is hydrogen or fluorine; Z2 is hydrogen, deuterium, or fluorine; Z3 is deuterium; Z4 is fluorine; m is an integer from 0 to 10; n is an integer from 0 to 2; provided that: the sum of m+n does not exceed 10; and when both Z1 and Z2 are hydrogen, the sum of m+n is greater than 0, and pharmaceutically acceptable salts thereof. This invention also provides compositions comprising one or more compounds of this invention and a carrier and the use of the disclosed compounds and compositions in methods of treating diseases and conditions that are beneficially treated by administering an antihelminthic agent, such as praziquantel. |
申请公布号 |
US2016083385(A1) |
申请公布日期 |
2016.03.24 |
申请号 |
US201514958461 |
申请日期 |
2015.12.03 |
申请人 |
Concert Pharmaceuticals, Inc. |
发明人 |
Liu Julie F.;Harbeson Scott L.;Tung Roger D. |
分类号 |
C07D471/04;C07B59/00;A61K31/4985 |
主分类号 |
C07D471/04 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
Lexington MA US |