发明名称 |
ANTIBODIES CAPABLE OF BINDING TWO EPITOPES ON TISSUE FACTOR PATHWAY INHIBITOR (1-161) |
摘要 |
The application discloses bispecific TFPI antibodies that are capable of specifically and simultaneously binding two epitopes within TFPI (1-161). Such bispecific antibodies strongly enhance thrombin generation by neutralising TFPI, even where the concentration of TFPI is elevated. Bispecific antibodies of the invention or compositions comprising them may be used for the treatment of subjects with a coagulopathy. |
申请公布号 |
WO2016042093(A1) |
申请公布日期 |
2016.03.24 |
申请号 |
WO2015EP71359 |
申请日期 |
2015.09.17 |
申请人 |
NOVO NORDISK A/S |
发明人 |
PETERSEN, HELLE HEIBROCH;KROGH, BERIT OLSEN;BREINHOLT, JENS;KOFOD-HANSEN, MIKAEL;HILDEN, IDA |
分类号 |
C07K16/38;A61K39/395;C07K16/46 |
主分类号 |
C07K16/38 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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