| 摘要 |
The invention provides novel compounds having the general formula:;;wherein R1, R2, R3, R4, R5, R6, X, Y, W and n are as described herein, compositions including the compounds and methods of using the compounds. |
| 主权项 |
1. A compound of formula (I) wherein R1 is hydrogen, halogen or C1-6alkyl; R2 is hydrogen or halogen; R3 is hydrogen or halogen; R4 is C1-6alkyl; R5 is hydrogen, hydroxyC1-6alkyl, aminocarbonyl, C1-6alkoxycarbonyl or carboxy; R6 is hydrogen, C1-6alkoxycarbonyl or carboxy-CmH2m—; X is carbonyl or sulfonyl; Y is —CH2—, —O— or —N(R7)—,
wherein R7 is hydrogen, C1-6alkyl, haloC1-6alkyl, C3-7cycloalkyl-CmH2m—, C1-6alkoxycarbonyl-CmH2m—, —CtH2t—COOH, -haloC1-6alkyl-COOH, —(C1-6alkoxy)C1-6alkyl-COOH, —C1-6alkyl-O—C1-6alkyl-COOH, —C3-7cycloalkyl-CmH2m—COOH, —CmH2m—C3-7cycloalkyl-COOH, hydroxy-CtH2t, carboxyspiro[3.3]heptyl, carboxyphenyl-CmH2m— or carboxypyridinyl-CmH2m—; W is —CH2—, —C(C1-6alkyl)2-, —O— or carbonyl; n is 0 or 1; m is 0-7; and t is 1-7; or a pharmaceutically acceptable salt, enantiomer, or diastereomer thereof. |
