发明名称 |
SQUALENE COMPOUNDS AS MODULATORS OF LDL-RECEPTOR EXPRESSION |
摘要 |
The present invention relates to compounds that modify low density lipoprotein receptor (LDLR) expression. The compounds have the structural formula I shown below: wherein m, R1, n, R2 and R3 are each as defined herein. The present invention also relates to processes for the preparation of these compounds, to pharmaceutical compositions comprising them, and to their use in the treatment of diseases or disorders associated with elevated levels of low density lipoprotein cholesterol (LDL-C). |
申请公布号 |
WO2016042318(A1) |
申请公布日期 |
2016.03.24 |
申请号 |
WO2015GB52673 |
申请日期 |
2015.09.15 |
申请人 |
ISIS INNOVATION LIMITED |
发明人 |
WYNNE, GRAHAM MICHAEL;RUSSELL, ANGELA JANE;MASON, JOSEPH;BATAILLE, CAROLE JEANNE RACHELE;WADE-MARTINS, RICHARD;KERR, ALASTAIR;HIBBITT, OLIVIA;TAM, LAWRENCE |
分类号 |
A61K31/00;A61K31/138;A61P3/06 |
主分类号 |
A61K31/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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