发明名称 |
LIPOSOMAL FORMULATIONS OF POLYMYXIN AND USES THEREOF |
摘要 |
The present invention provides novel liposomal formulations of polymyxin B and pharmaceutical compositions thereof useful for the treatment of bacterial infections. The liposomal formulation comprises a lipid component formed as vesicles each having a minimum size of at least 500 nm and polymyxin B encapsulated in the vesicles. The present invention also provides a drug delivery system that comprises a plurality of liposomes encapsulating a polymyxin B therein, where the liposomes have a minimum vesicular size of at least 500 nm. The liposomes comprising the drug delivery system are useful to increase efficacy of a treatment for a bacterial infection by increasing bioavailability and distribution of the polymyxin B within the subject. |
申请公布号 |
EP2884989(A4) |
申请公布日期 |
2016.03.23 |
申请号 |
EP20130829139 |
申请日期 |
2013.05.22 |
申请人 |
UNIVERSITY OF HOUSTON SYSTEM |
发明人 |
TAM, VINCENT;CHOW, DIANA;HE, JIE |
分类号 |
A61K38/12;A61K9/00;A61K9/127;A61K47/24;A61P31/04 |
主分类号 |
A61K38/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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