发明名称 |
RNAI PHARMACEUTICAL COMPOSITION CAPABLE OF SUPPRESSING EXPRESSION OF KRAS GENE |
摘要 |
The present invention provides a composition for suppressing the expression of a KRAS gene, comprising a lipid particle containing, as a drug, a double-stranded nucleic acid having an antisense strand having a sequence of bases complementary to the sequence of at least 19 continuous bases of any one KRAS gene's mRNA of sequence Nos. 1 to 3; and
a cationic lipid represented by the following formula (I):
wherein
R 1 and R 2 , which are the same or different, are each linear or branched alkyl, alkenyl or alkynyl having a carbon number of from 12 to 24;
L 1 and L 2 , which are the same or different, are each -CO-O- or -O-CO-;
a and b, which are the same or different, are each 1 to 3; and
R 3 is a hydrogen atom, alkyl having a carbon number of from 1 to 6, or alkenyl having a carbon number of from 3 to 6, and the like. |
申请公布号 |
EP2873732(A4) |
申请公布日期 |
2016.03.23 |
申请号 |
EP20130820367 |
申请日期 |
2013.07.16 |
申请人 |
KYOWA HAKKO KIRIN CO., LTD.;DICERNA PHARMACEUTICALS, INC. |
发明人 |
NAOI, TOMOYUKI;KUBOYAMA, TAKESHI;ENOKIZONO, JUNICHI;ISHII, TOSHIHIKO;TOKUNAGA, AKIHIRO;HATANAKA, KENTAROU |
分类号 |
C07H21/02;A61K9/127;A61K31/713;C12N15/113 |
主分类号 |
C07H21/02 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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