发明名称 |
MODEL OF ALZHEIMER'S DISEASE |
摘要 |
The invention features a non-transgenic rat model for early AD, using a metal mixture of As, Cd and Pb, characterized by enhanced synergistic amyloidogenicity in rat cortex and hippocampus. This model can serve as a tool for (a) AD-directed drug screening, and (b) determining mechanism of AD pathogenicity. It features induction of the A?-mediated apoptosis and induction of inflammation in rodent brain. The invention features novel astrocyte and neuronal cellular models for AD, using a metal mixture of As, Cd and Pb, characterized by enhanced synergistic amyloidogenicity. This model can serve as a tool for (a) AD-directed drug screening in astrocytes and neurons, and (b) determining mechanism of AD pathogenicity in cells. It features induction of the A?-mediated apoptosis and induction of inflammation in astrocytes and neurons. |
申请公布号 |
EP2997136(A1) |
申请公布日期 |
2016.03.23 |
申请号 |
EP20140734244 |
申请日期 |
2014.05.15 |
申请人 |
COUNCIL OF SCIENTIFIC & INDUSTRIAL RESEARCH |
发明人 |
BANDYOPADHYAY, SANGHAMITRA;ASHOK, ANUSHRUTI;RAI, NAGENDRA KUMAR;RAI, ASIT;TRIPATHI, SACHIN |
分类号 |
C12N5/079;G01N33/50;G01N33/68 |
主分类号 |
C12N5/079 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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