发明名称 |
APPARATUS AND METHOD FOR MEASURING CONCENTRATION OF AN ANALYTE IN WHOLE BLOOD SAMPLES |
摘要 |
A method for measuring a concentration of an analyte in a bio-sample using an electrochemical bio-sensor according to an exemplary embodiment of the present invention is characterized by a step of obtaining predetermined features from induced currents obtained by applying a DC voltage according to chronoamperometry in which, after a whole blood sample is injected to the electrochemical bio-sensor, a concentration of an analyte is obtained from an induced current obtained by applying a DC voltage for a certain time and from all induced currents obtained by further applying several step-ladder perturbation potentials for a short time subsequent to the DC voltage for the certain time, and is also characterized by minimization of a measurement error caused by a hindering material by forming a calibration equation by combining the at least one feature in a function and optimizing various conditions of the bio-sample throughDeletedTextsmultivariable analysis. With this configuration, a perturbation potential application method added to a conventional measurement method can maintain a bio-sensor and a measuring apparatus already used, a line used in the measuring apparatus, and calibration of amperometry as they are, improve accuracy in measurement by effectively minimizing a matrix interference effect of a background material in a bio-sample, particularly an inaccuracy caused by a change in hematocrit, and also remarkably improve accuracy in measurement by simply upgrading a measurement program of a conventional measuring apparatus. |
申请公布号 |
EP2998731(A1) |
申请公布日期 |
2016.03.23 |
申请号 |
EP20140192132 |
申请日期 |
2014.11.06 |
申请人 |
I-SENS, INC. |
发明人 |
CHA, GEUN SIG;NAM, HAKHYUN;LEE, SEOK-WON;CHOI, SUNG HYUK;KANG, YOUNGJEA;LEE, MYEONGHO;PARK, HO DONG;CHO, SUNG PIL |
分类号 |
G01N27/327;G01N33/487;G01N33/49 |
主分类号 |
G01N27/327 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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