发明名称 |
Activation of TRPV4 ion channel by physical stimuli and critical role for TRPV4 in organ-specific inflammation and itch |
摘要 |
Provided are TRPV4 inhibitor compounds. Further provided are compositions including a TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application. The TRPV4 inhibitor compounds and compositions may be used in methods of treating and/or preventing dermatological disorders, reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. |
申请公布号 |
US9290489(B2) |
申请公布日期 |
2016.03.22 |
申请号 |
US201314413172 |
申请日期 |
2013.07.05 |
申请人 |
Duke University |
发明人 |
Liedtke Wolfgang;Guilak Farshid |
分类号 |
C07D417/04;A61K31/4439;A01K67/027;C07K14/705;C07D277/42;G01N33/68 |
主分类号 |
C07D417/04 |
代理机构 |
Michael Best & Friedrich LLP |
代理人 |
Michael Best & Friedrich LLP |
主权项 |
1. A compound selected from the following: |
地址 |
Durham NC US |