| 主权项 |
1. A compound of formula (I) wherein A is —O—, —S—, —CH2—, —NH— or —SO2—; B is phenyl, substituted phenyl, pyrrolidinyl, substituted pyrrolidinyl, pyridinyl, substituted pyridinyl, pyrimidinyl, substituted pyrimidinyl, 1,2,3,4-tetrahydronaphtalenyl, bicyclo[4.2.0]octa-1(6),2,4-trienyl, indanyl or 6,7,8,9-tetrahydro-5H-benzocycloheptenyl, wherein substituted phenyl is phenyl substituted with one or two substituents each of which is independently halogen, alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, alkoxy, haloalkyl, azetidinyl, alkylsulfanyl or cyano, wherein substituted pyrrolidinyl is pyrrolidinyl substituted with one or two substituents each of which is independently halogen, alkyl, alkoxy, haloalkoxy, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, alkylsulfanyl, alkylsulfonyl, cyclopropylsulfanyl, cyclobutylsulfanyl, cyclopentylsulfanyl, cyclohexylsulfanyl, cycloheptylsulfanyl, cyclooctylsulfanyl, cyclopropylsulfonyl, cyclobutylsulfonyl, cyclopentylsulfonyl, cyclohexylsulfonyl, cycloheptylsulfonyl and cyclooctylsulfonyl, wherein substituted pyridinyl is pyridinyl substituted with halogen, alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, alkoxy or haloalkoxy, and wherein substituted pyrimidinyl is pyrimidinyl substituted with halogen, alkyl, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl, alkoxy or haloalkoxy; D is —O—, —S—, —CH2—, —NH— or —SO2—; one of R1, R2, R3 and R4 is hydrogen and the other ones are independently selected from hydrogen, halogen, alkyl, alkoxy, haloalkoxy, cyclopropyl, cyclobutyl, cyclopentyl, cyclohexyl, cycloheptyl, cyclooctyl and phenyl; or R5 and R6 together with the carbon atom to which they are attached form cyclopropyl; and is a carbon-carbon single bond or a carbon-carbon double bond; or a pharmaceutically acceptable salt or ester thereof. |
