| 发明名称 | Kit for identifying regulatory T cells | ||
| 摘要 | The present invention relates to methods and kits for identifying, quantifying and isolating regulatory T cells, to methods and kits for diagnosing or monitoring autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer, cancer treatment and/or organ transplantation based on regulatory T cell quantity, to methods and kits for predicting responses to therapy for autoimmune diseases, immunoinflammatory diseases, allergic diseases, predispositions thereto, infectious diseases, cancer and/or organ transplantation based on regulatory T cell quantity, and to methods and kits for therapy using isolated regulatory T cells. | ||
| 申请公布号 | US9291623(B2) | 申请公布日期 | 2016.03.22 |
| 申请号 | US201113087910 | 申请日期 | 2011.04.15 |
| 申请人 | CENTENARY INSTITUTE OF CANCER MEDICINE AND CELL BIOLOGY | 发明人 | Fazekas De St Groth Barbara Denise;Kelleher Anthony Dominic;Landay Alan Lee;Sasson Sarah Christina;Seddiki Nabila;Zaunders John James |
| 分类号 | C07K16/28;G01N33/569;C12N5/0783 | 主分类号 | C07K16/28 |
| 代理机构 | McDermott Will & Emery LLP | 代理人 | McDermott Will & Emery LLP |
| 主权项 | 1. A kit for identifying in a primate subject a regulatory T cell or a population of regulatory T cells, the kit comprising: at least one antibody for determining a level of cellular expression of CD127, at least one antibody for determining a level of cellular expression of CD4 and at least one antibody for determining a level of cellular expression of CD25 in a primate subject, wherein a determined expression level of CD127lowCD4+CD25+ is indicative of a regulatory T cell or a population of regulatory T cells. | ||
| 地址 | New South Wales AU | ||