Compositions and methods for treating bone conditions

摘要

A method of treating a degenerative bone condition of a subject includes administering to hematopoietic progenitor cells or osteoclast progenitor cells of the subject at least one agent that substantially reduces the interaction of at least one of C3a or C5a with the C3a receptor (C3aR) and/or C5a receptor (C5aR), a STAT3/IL-6 signaling pathway antagonist, and a combination thereof, the agent being administered to the hematopoietic progenitor cells or osteoclast progenitor cells at an amount effective to inhibit osteoclast differentiation of hematopoietic progenitor cells or osteoclast progenitor cells.

主权项

1. A method of treating a degenerative bone condition in a subject in need thereof, the method comprising:
administering locally to hematopoietic progenitor cells or osteoclast progenitor cells a C3a receptor (C3aR) antagonist directed against C3aR, the C3aR antagonist being administered to the hematopoietic progenitor cells or osteoclast progenitor cells at an amount effective to inhibit osteoclast differentiation of the hematopoietic progenitor cells or osteoclast progenitor cells, the hematopoietic progenitor cells or osteoclast progenitor cells being in the subject or administered to the subject.