Pharmaceutical composition for treating diabetes

摘要

Provided is a compound represented by the following general formula (I), or a pharmaceutically acceptable salt thereof. This novel compound has a glycogen-synthase activation ability, but activates a receptor PPAR to a low degree and is highly safe.;;In the formula, Ar is an aromatic carbocyclic ring or a heterocyclic ring; and Ar2 is represented by any one of the following rings and the like.;

主权项

1. A compound of formula (I): wherein Ar is an aromatic carbocyclic ring or a heterocyclic ring; Ar2 is represented by any one of the following rings these rings may have a substituent, and the substituent is selected from the group consisting of acetamido, aminocarbonyl, benzyl, benzyloxy, a halogen, hydroxyl-lower alkyl, lower alkyl, lower alkoxy-lower alkyl, phenoxy, phenyl, a formyl group, a cyano group, a cyanoalkyl group, a hydroxyiminomethyl group, a hydroxyamidino group, an amino group, an aminoalkyl group, an alkylaminoalkyl group, a dialkylaminoalkyl group, lower alkoxy, and trifluoro-methoxy; R2 and R3 are independently selected from the group consisting of lower alkyl, lower alkoxy, trifluoromethyl, a halogen, hydroxy, a hydroxyl-lower alkyl group, amino, alkylamino, dialkylamino, cyano, and nitro; R4 is an amino acid residue bonded to C(O) through a nitrogen atom of the amino acid; m is 0, 1, 2, 3, or 4; p is 0, 1, or 2; and s is 0, 1, or 2, or a pharmaceutically acceptable salt thereof.