| 发明名称 |
Methods of synthesizing a levodopa ester prodrug |
| 摘要 |
Methods of synthesizing a levodopa ester prodrug, salts thereof, and synthetic intermediates thereof are disclosed. |
| 申请公布号 |
US9290445(B2) |
申请公布日期 |
2016.03.22 |
| 申请号 |
US200912581808 |
申请日期 |
2009.10.19 |
| 申请人 |
XenoPort, Inc. |
发明人 |
Raillard Stephen P.;Mann Adam;Manthati Suresh K.;Scheuerman Randall A.;Estrada Tono;Nguyen Mark Q.;Zhou Cindy X |
| 分类号 |
C07C269/06;C07C67/20;C07C227/20;C07C269/04 |
主分类号 |
C07C269/06 |
| 代理机构 |
|
代理人 |
|
| 主权项 |
1. A method of synthesizing (2R)-2-phenylcarbonyloxypropyl(2S)-2-amino-3-(3,4-dihydroxyphenyl)propanoate comprising reacting 3-(3,4-dihydroxyphenyl)-(2S)-[tert-butoxy)carbonylamino]propanoate tetraalkylammonium salt with (1R)-2-chloro-isopropyl benzoate in N-methyl-2-pyrrolidone to provide (2R)-2-phenylcarbonyloxypropyl(2S)-3-(3,4-dihydroxyphenyl)-2-[(tert-butoxy)carbonylamino]propanoate. |
| 地址 |
Santa Clara CA US |
