Wound healing compositions and treatments

摘要

This invention concerns improved methods, uses, and kits for treating chronic wounds through the administration of anti-connexin agents, particularly anti-connexin 43 antisense polynucleotides. The methods, uses, and kits of the invention are based on the surprising and unexpected discovery that chronic wounds that do not increase or decrease in size by more than a pre-determined amount during a pre-treatment phase are more amenable to successful treatment than wounds whose size varies outside the target range during the pre-treatment phase.

主权项

1. An article of manufacture for use in treating a refractory wound, comprising a receptacle containing a composition comprising a pharmaceutical carrier suitable for topical administration having about 20-23% of a nonionic polyoxyethylene-polyoxypropylene and about 3-30 mg/mL of an anti-connexin oligodeoxynucleotide to a connexin selected from connexin 26, connexin 30 and connexin 43, and instructions for the treatment of the refractory wound, by topically administering the composition to or in the proximity of the wound.