| 发明名称 | Soluble TCR molecules and methods of use | ||
| 摘要 | Disclosed are compositions and methods for detecting cells or tissue comprising a peptide antigen presented in the context of an MHC or HLA complex. The invention has a wide range of applications including providing a highly sensitive method for detecting cancer cells. | ||
| 申请公布号 | US9290560(B2) | 申请公布日期 | 2016.03.22 |
| 申请号 | US201414182888 | 申请日期 | 2014.02.18 |
| 申请人 | ALTOR BIOSCIENCE CORPORATION | 发明人 | Price-Schiavi Shari A.;Belmont Heather J.;Card Kimberlyn F.;Zhu Xiaoyun;Wong Hing C. |
| 分类号 | C07K1/00;C07K14/00;C07K17/00;C07K14/725;A61K47/48;B82Y5/00;C07K14/55;G01N33/574;G01N33/68 | 主分类号 | C07K1/00 |
| 代理机构 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. | 代理人 | Mintz Levin Cohn Ferris Glovsky and Popeo, P.C. ;Corless, Esq. Peter F.;Clarke Daniel W. |
| 主权项 | 1. A soluble T cell receptor (TCR) fusion complex comprising a Vα chain, a Vβ chain, a Cβ chain, and an interleukin-2 (IL-2) domain, wherein the TCR is capable of binding to a p53 peptide in the context of an MHC molecule, wherein the MHC molecule comprises an HLA-A2 molecule, and wherein the soluble TCR fusion complex comprises the amino acid sequence set forth in SEQ ID NO: 16. | ||
| 地址 | Miramar FL US | ||