发明名称 |
Preparation of 4-amino-2,4-dioxobutanoic acid |
摘要 |
A process for synthesizing 4-amino-2,4-dioxobutanoic acid involves reacting diethyl oxalate with an alkoxide in ethanol to form a reaction mixture, and afterward adding ethyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl 2-cyano-3-hydroxy-butenedioate, and then isolating the diethyl 2-cyano-3-hydroxy-butenedioate, and afterward reacting the diethyl-2-cyano-3-hydroxy-butenedioate with an aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid. |
申请公布号 |
US9290442(B2) |
申请公布日期 |
2016.03.22 |
申请号 |
US201414486423 |
申请日期 |
2014.09.15 |
申请人 |
Los Alamos National Security, LLC;New Mexico Highlands University |
发明人 |
Unkefer Pat J.;Martinez Rodolfo A.;Glass David R. |
分类号 |
C07C229/00;C07C231/06;C07C253/30 |
主分类号 |
C07C229/00 |
代理机构 |
|
代理人 |
Miller Mark D.;Nelson William K. |
主权项 |
1. A process for synthesizing 4-amino-2,4-dioxobutanoic acid, comprising:
reacting diethyl oxalate with an alkoxide in an alcoholic solvent to form a reaction mixture, and afterward adding ethyl cyanoacetate to the reaction mixture and allowing a reaction to proceed under conditions suitable to form a first reaction product of the formula diethyl 2-cyano-3-hydroxy-butenedioate, isolating said first reaction product of diethyl 2-cyano-3-hydroxy-butenedioate, and reacting said first reaction product of diethyl 2-cyano-3-hydroxy-butenedioate with aqueous hydroxide under conditions suitable to form 4-amino-2,4-dioxobutanoic acid. |
地址 |
Los Alamos NM US |