Bicyclic compound

摘要

Provided is a pharmaceutical agent containing a compound represented by General Formula (1), a pharmaceutically acceptable salt thereof, or a solvate thereof:;
wherein A represents a C1-C3 linear alkylene group, in which one methylene group is optionally substituted with O or S;

n represents an integer of from 3 to 5;

X1 and X2 each independently represent CH or N;

W1 and W2 each independently represent a carboxyl group or a tetrazolyl group;

V represents a C1-C8 linear or branched alkylene group, in which one methylene group is optionally substituted with O or S; and

R represents a substituted phenyl group, for example.

主权项

1. A compound of Formula (1): wherein A represents a C1-C3 linear alkylene group, in which one methylene group is optionally substituted with O or S; n represents an integer of from 3 to 5; X1 and X2 each independently represent CH or N; W1 and W2 each independently represent a carboxyl group or a tetrazolyl group; V represents a C1-C8 linear or branched alkylene group, in which one methylene group is optionally substituted with O or S; R represents a group selected from the group consisting of: in which R1, R2, R3, R4 and R5 represent a hydrogen atom, a halogen atom, a C1-C6 alkyl group which optionally comprises a substituent group, a C1-C6 alkoxy group, a C3-C6 cycloalkyl group, a C3-C6 cycloalkoxy group, a halo C1-C4 alkyl group, a halo C1-C4 alkoxy group, a vinyl group which optionally comprises a substituent group, an ethynyl group which optionally comprises a substituent group, an aryl group which optionally comprises a substituent group on an aromatic ring, an aryloxy group which optionally comprises a substituent group on an aromatic ring, a benzyl group which optionally comprises a substituent group on a benzene ring, a phenethyl group which optionally comprises a substituent group on a benzene ring, a benzyloxy group which optionally comprises a substituent group on a benzene ring, a benzylsulfanyl group which optionally comprises a substituent group on a benzene ring, a benzylamino group which optionally comprises a substituent group on a benzene ring, a phenyloxymethyl group which optionally comprises a substituent group on a benzene ring, a phenylsulfanylmethyl group which optionally comprises a substituent group on a benzene ring, or a phenylaminomethyl group which optionally comprises a substituent group on a benzene ring; m represents an integer of 1 or 2; and Y1 and Y2 each independently represent methylene, O or S, with the proviso that Y1 and Y2 do not simultaneously represent S, a pharmaceutically acceptable salt thereof, or a solvate thereof.