Process for preparing cinacalcet and pharmaceutically acceptable salts thereof

摘要

The present patent application relates to a process for preparing, cinacalcet or a pharmaceutically acceptable salt thereof, which comprises reacting 3-trifluoromethylbenzaldehyde having the following formula (II) with the phosphorus-comprising derivative having the following formula (III) in which R1 and R2, which may be identical or different, are each a (C1-C6)alkyl group. The present invention also relates to the phosphorus-comprising derivative having the formula (III), to the use thereof and to the process for preparing same. The present invention also relates to the phosphate salt of cinacalcet and to uses thereof.

主权项

1. A process for preparing cinacalcet or one of the pharmaceutically acceptable salts thereof, comprising the reaction of 3-trifluoromethyl-benzaldehyde of following formula (II):with the phosphorus-containing derivative of following formula (III):where R1 and R2, the same or different, each represent a (C1—C6)alkyl group.