Systems and methods for imaging changes in tissue

摘要

The present invention provides systems and methods for monitoring tissue regions. In particular, the present invention provides systems and methods for detecting changes in tissue regions over a period of time. In some embodiments, the systems and methods of the present invention are used to evaluate the effectiveness of a particular treatment of a tissue region. In some embodiments, the systems and methods of the present invention provide a parametric response map approach for detecting and analyzing changes in tissue regions over a period of time to detect and monitor disease or tissue health and to monitor the impact of therapeutic interventions.

主权项

1. A computer-based method for generating a parametric response map comprising:
a) obtaining a first set of parametric measurement data for a tissue region with an imaging device, the first set of parametric measurement data comprising a plurality of voxels; b) administering a treatment to the tissue region; c) obtaining one or more subsequent sets of parametric measurement data, each subsequent set of parametric measurement data comprising a plurality of voxels, and the subsequent sets of parametric measurement data being obtained with the imaging device or another imaging device; d) registering the one or more subsequent sets of parametric response data with the first set of parametric response data; and e) identifying, on a voxel-by-voxel basis, whether the voxels within the tissue region have increased, decreased, or unaltered parametric measurement properties, using a defined threshold, wherein each of the changes is determined by comparing voxels of the one or more subsequent sets of parametric measurement data to the voxels of one or more subsequent sets of parametric measurement data obtained previously or to the voxels of the first set of parametric measurement data.